Abstract 48. Stem Cells Harvested from Bone Marrow and Adipose Tissue Demonstrate Differential Healing Mechanisms and Union Rates in a Murine Model of Irradiated Mandibular Fracture Repair
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چکیده
METHODS: Custom 3DBC scaffolds were either coated with collagen (control) or coated with collagen and immersed in 100 μM dipyridamole (DIPY). Sheep (n=5) were subjected to 4 trephine-induced (12 mm diameter) calvarial defects with immediate scaffold placement via two separate operations: anteriorly (control) and posteriorly (DIPY) on the right (3 weeks healing) and left (6 weeks healing) sides of the calvarium. Following sacrifice, defects were evaluated through microcomputed tomography and histologic analysis for bone, scaffold, and soft tissue quantification as a function of time in vivo. Statistical analysis was performed by a mixed model and significance was defined by p<0.05.
منابع مشابه
Abstract 69: Stem Cells Harvested from Bone Marrow and Adipose Tissue Demonstrate Equivalent Healing but Through Different Mechanisms in a Murine Model of Irradiated Mandibular Fracture Healing
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